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Theodent is the absolute best toothpaste formulation on the market, the world's only absolutely safe alternative to kinds of toothpaste containing fluoride. It took more than 30 years of continuous clinical studies to create a unique revolutionary formula Rennou, a proprietary blend of cocoa extract and other minerals, which is unique worldwide. This active ingredient in the toothpaste increases the size of enamel surface crystals, making teeth less susceptible to bacterial acid demineralization. All components of Theodent are of natural origin, therefore completely harmless to health, even if accidentally swallowed. The prestigious G.R.A.S. status confirms the complete safety of the product according to the standards of the FDA.


The daily consumption of large quantities of acidic food and drinks causes erosion of enamel, one of the reasons for increased tooth sensitivity. Today, fluorine is commonly used in the toothpastes for enamel remineralization. But fluoride strengthens teeth by adhering to and incorporating itself into the tooth. Fluoride is also known to be a neurotoxin and its overabundance in the body can be very harmful. The recent Harvard studies have shown it's correlated to lower IQ levels in children.


The academic research behind Theodent was first conducted in the 1980s by Dr. Tetsuo Nakamoto, a co-founder of the company and a professor at the Louisiana State University Health Sciences Center in New Orleans. He studied the effects of nutritional constituents on pre-natal teeth. In collaboration with Professors Alexander Falster and William Simmons, experts in analytical geology, Nakamoto found that dark chocolate without the fat and sugar helps prevent the development of caries in its early stages. They discovered that enamel remineralization occurs due to its theobromine constituent, a cocoa extract similar in structure to caffeine, effective in fighting cavities and strengthening tooth enamel. The finding caused extensive researches and led to the creation of Rennou revolutionary formula, the active ingredient of Theodent toothpaste.

The research of a momentous discovery was taken a step further by Dr. Arman Sadeghpour in 2007. As a part of the doctoral dissertation at Tulane University, he tested the theobromine on human teeth and make a comparison of cocoa extract and fluoride abilities to strengthen tooth enamel. The research confirmed the earlier finding of Dr. Nakamoto. The interest towards the product made the scientists work on commercializing the technology. Theodent LLC was established by Sadeghpour and Nakamoto in cooperation with William Simmons and Joseph Fuselier. The company’s first commercial product was launched in 2012. The company now holds three patents issued in the USA and a third worldwide patent pending. Theodent LLC is supported by the New Orleans BioInnovation center. It is a nonprofit business incubator, a hub for bioscience companies in Louisiana. The organization supports teams developing innovative medical devices, diagnostics, therapeutics, digital health platforms, clean technologies, etc.


The basis of the revolutionary RENNOU formula is theobromine, a substance of natural origin derived from cocoa beans. Theobromine has antibacterial properties and actively promotes the remineralization of enamel. It stimulates the formation of hydroxyapatite crystals, the main component of the bone tissue of the tooth. Moreover, these new crystals of hydroxyapatite, formed on the surface of exposed dentin and within the dentinal tubules, are four times larger and stronger than the previous ones and much more resistant to external acids (wine, juices, fruits, etc.). In comparison to fluorine that incorporates itself into the tooth, the cocoa extract strengthens and enlarges the crystals that make up the tooth, resulting in a more robust enamel. Theobromine is totally safe for health and exceeds greatly the performance of fluorine (71 times less theobromine is needed to show the same results in comparison to fluorine). Thus, when regularly used, the Theodent toothpaste allows to eliminate the problems of tooth sensitivity and stop the development of caries at an early stage. All the ingredients of Theodent formula closely interact with each other providing a high performance of the product. Thus, in addition to theobromine, the toothpaste also includes calcium acetate that restores positive calcium balance and sodium phosphate, a buffer for the absorption of calcium and growth of hydroxyapatite crystals. A range of ingredients is set to fight the bad bacteria.

Xylitol is needed for the prevention of caries as it inhibits the growth of pathogenic microorganisms and helps to neutralize acidic environment in the mouth.

Citric acid has a broad-spectrum antiseptic effect, thus killing harmful bacteria and preventing decay of soft tissues.

Sodium benzoate suppresses the activity of enzymes in microbial cells responsible for the redox reaction.

Peppermint oil has antiseptic, anti-inflammatory and deodorizing effect as well as a sorbitol having an antibacterial effect.

Soda microparticles are responsible for the mechanical removal of microbes removing plaque while gently polishing the enamel.

In addition to soda, Theodent formula comprises also another mild natural abrasive, titanium dioxide. It gently cleanses the enamel and is a natural concealer restoring the natural white color of the teeth.

Even the foaming agent in the composition of the paste is of vegetable origin. It is sodium lauroyl sarcosinate instead of commonly used sodium lauryl sulfate.

Vanilla extract gives a light aroma and influences greatly the flavor of the paste, especially when combined with menthol and extract of stevia (one of the most famous natural sweeteners). Efficacy and safety Theodent toothpaste were proved in more than 80 studies, including independent. Its effectiveness is confirmed by reputable medical organizations:

Tulane University, the LSU school of Dentistry, the University of New Orleans, the University of Texas at San Antonio; the University of Texas at Austin; Department of Pediatric Dentistry, Marmara University Dental School.


  • Restores mineral composition and density of the tooth enamel;
  • Stimulates the growth of a stronger enamel;
  • Completely removes sensitive after 7 days of usage;
  • Gently cleanses the enamel, as the toothpaste has one of the lowest index of relative dentin abrasivity among toothpastes, less than 40;
  • Retains purity and smoothness of teeth throughout the day;
  • Neutralizes acid produced by bacteria and prevents their further reproduction;
  • It is an easy natural bleaching agent whitening teeth;
  • The ideal solution for those who have weak enamel and has contraindication for peroxide bleaching;
  • Increases the effect of whitening and professional cleaning by preventing the formation of plaque and staining;
  • It does not contain fluorine and SLS and is safe if swallowed.

Theodent is the world's first toothpaste, that has received the highest security status G.R.A.S. (Generally Recognized as Safe), previously assigned only to foods. The product is approved by the American Dental Association (ADA), the Food and Drug Administration (US FDA). Theodent is manufactured in accordance with ISO 13485:2003 (quality assurance, safety innovations). It has EAC and EurAsEC certificates of conformity.

Theodent has been awarded GRAS status, the highest food safety standard by the US FDA Source - Theodent Russia

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