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Trust the world's best fluoride-free toothpaste

Discover the revolutionary fluoride-free toothpaste that provides you with a sparkling smile without fear of harmful ingredients - Theodent!

Theodent products


Theodent Classic


Theodent Kids


Theodent 300


Theodent PACK3


What Makes Theodent the #1 Alternative to Fluoride?

Theodent is a landmark breakthrough in oral care. Our patented technology, Rennou™, harnesses the power of cacao to deliver top-tier protection, without the toxicity. Simply, Theodent is a safer, AND more effective option than fluoride-based toothpastes.

Some of Today’s Greatest Medical Technologies Emerged by Mere Chance

Penicillin. X-rays. Insulin. Many of our most important medical applications since the late 19th century were not planned destinations. They were detours.

Before Theodent introduced a new class of luxury toothpaste, it was also a detour. Our product follows a distinguished line of “accidental” discoveries that have catapulted science forward in profound ways.

Theodent’s role in upending traditional views on fluoride cannot be overstated. To see why, we have to understand how something as routine as brushing is so important in the first place.

Oral Care Isn’t Just About Dental Health, It’s About Your Overall Health

We are told from an early age that brushing is important. It keeps our mouths clean, our teeth pretty, and our breath fresh.

What we hear less often is how imperative it is to the rest of our bodies.

Just as they take in the food we eat and air we breathe, our mouths are also gateways for harmful bacteria and infections, which may lead to complications in our bones, heart, kidneys, and other organs.

Dental hygiene is therefore a first line of defense since issues like cavities and gum disease weaken our ability to fight off invaders at the source. Simply put, our broader wellbeing hinges greatly on a healthy smile.

Our Natural Defenses Take Us Only So Far

Teeth play an important role in many of our internal systems. This includes housing vital nerves and blood vessels in the mouth. To safeguard them, our teeth build multiple layers of protection starting with enamel. The hardest tissue in the body, enamel is mostly made of a mineral called hydroxylapatite, which looks like a cluster of tiny crystals when seen under a microscope.

The layer beneath your enamel is known as dentin. Although dentin is also a hard tissue, it is porous and contains small tubes leading to the nerves in your teeth.

Dentin is gradually exposed as your enamel erodes over time. When that happens, your teeth become hypersensitive and painful. Continued exposure eventually causes dentin decay and cavities. Fruit juice, soft drinks, wine, and other acidic and sugary products can accelerate this process, especially when combined with poor hygiene habits.

Fluoride: A Once-Popular Solution That’s Lost Its Appeal

Over 100 years ago, scientists found that fluoride could help prevent tooth decay. Widespread commercial production of fluoride-based toothpastes then began in the 1950s. These products have been considered the standard ever since and make up the vast majority of global toothpaste sales.

However, when it comes to fluoride and long-term health, there’s a catch: fluoride is a poison.

Specifically, studies have shown fluoride to be a neurotoxicant. Even low levels of ingestion are toxic to the body. In fact, the FDA requires a warning on fluoride toothpaste urging a call to Poison Control if too much is swallowed.

Research has linked fluoride to conditions such as:

  • Reduced IQ in children (1)
  • Fluoride calcification or hardening of the pineal gland (2)
  • Dental fluorosis (tooth discoloration) (3)
  • Thyroid disease (4)
  • Skeletal fluorosis (bone disease) (5)

This is particularly concerning for developing children, who have been found to ingest as much as 75% of their toothpaste while brushing. Understanding you must spit out what tastes delicious is confusing for a child.

As important as it is to fight dental disease, protection of one aspect of our health cannot come at the cost of others. Why, then, has relatively little attention been given to this part of our everyday lives despite its crucial impact on our wellbeing?

Fortunately, growing awareness of fluoride’s adverse effects has combined with innovative science to usher in a new era of oral care.

Superior Tooth Protection Where No One Thought to Look

For decades, dental experts claimed fluoride to be the only chemical able to prevent tooth decay. This changed in the early 1990s thanks to a chance finding that not only led to an alternative, but one that is completely safe.

Researchers discovered that a molecule called theobromine grows enamel crystal structure in our teeth. Moreover, theobromine—which is readily found in, of all places, cacao—is far superior to fluoride in strengthening this structure. It creates larger, stronger crystals that better protect enamel and dentin, improve remineralization, and eliminate hypersensitivity.

And, critically, there’s no danger to your system if it’s swallowed.

Years of research and development followed. The team isolated theobromine in cacao while leaving out the harmful fats and sugars found in processed chocolate. They then combined this active ingredient with calcium and phosphate into a proprietary formula.

The introduction of “Rennou,” as the formula was named, marked an unprecedented moment in the history of dental health.

Rennou: The Safer, More Effective Alternative to Fluoride

Rennou became the foundation of a groundbreaking new toothpaste: Theodent.

Since 2012, Theodent has been the single-most effective alternative to fluoride-based toothpastes. It has outperformed leading brands such as Colgate and prescription toothpastes like Sensodyne Nupro 5000. Theodent also clearly surpasses other fluoride-free options that have simply removed fluoride rather than replacing it.

Data suggests that it takes 71 times more fluoride to produce the same remineralization effects as Rennou. After only one week of brushing twice a day, 100% of the tubes exposed in dentin are fully or partially protected. These are stronger results in less time than fluoride can provide, making Theodent significantly better at hardening teeth and reducing hypersensitivity.

Importantly, unlike fluoride, Theodent is nontoxic. It is not harmful if swallowed by people of any age, and therefore does not need the Poison Control warning required for all fluoride toothpastes. In short, Rennou-based Theodent exceeds the standards to meet the US FDA’s highest food safety designation.


Theodent: Refinement in Oral Care

Dental disease is one of humanity’s most common afflictions. It is also one of the most preventable. Through scientific discovery, we are learning that standard oral health treatments —such as fluoride—are no longer the best option. Instead, Theodent offers solutions that are safer, deliver better results, and meet the demands of a smarter marketplace.

Theodent is now being sold worldwide to discerning consumers, who seek out sophisticated products that support their overall wellness.

Dentists Approved

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Using Theodent can be a real game changer both for patient and the dentist.

Theodent 300 may represent the solution for cases in which dental sensitivity still persists in spite of our treatment.

Theodent Classic is a good, viable and solid option for a good oral health, maintaining an esthetic apperance.

Theodent Kids is the first choice for our children combining the advantages of Rennou (instead of Fluride) with a chocolate flavour which is enhancing it’s use.

Florin Lazarescu, DMD, MSc
Bucharest, Romania
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As a dental professional, I highly recommend Theodent Toothpaste to my patients due to its many benefits. First and foremost, the unique ingredient Rennou, which is derived from cocoa, has been shown to help strengthen and remineralize tooth enamel.

This means that regular use of Theodent Toothpaste can actually help prevent tooth decay and cavities. Additionally, Theodent Toothpaste is made with all-natural ingredients and is free from harsh chemicals, making it a safe and gentle option for those with sensitive teeth or gums. It's also effective at removing surface stains, leaving teeth looking whiter and brighter. Overall, I believe that Theodent Toothpaste is an excellent choice for anyone looking to improve their oral health and hygiene routine.

Its natural ingredients and proven benefits make it a reliable and effective option for maintaining a healthy smile.

Dr. Nikolia Tzolova, aesthetic dentistry Owner of Perla Clinic and Owner of luxury medical clothing brand L'Ateleir La Perla
Sofia, Bulgaria

Committed to Premium Ingredients

At Theodent, we are committed to using only the best ingredients in our toothpaste. We carefully select each ingredient and subject them to a rigorous quality control process to ensure that our toothpaste is of the highest quality. This dedication to premium ingredients allows us to provide our customers with a superior oral care experience.

To produce the most premium toothpaste in the world, it all starts with the ingredients. Each ingredient in our toothpaste is carefully selected to serve a unique purpose for our formulation. Prior to each production, there are multiple layers of quality control tests to ensure that each ingredient that goes into your tube is of the highest grade possible. Theodent is committed to evolving our formulation to meet global health standards, and the needs of clinicians and our customers worldwide.

  • Rennou™ - the active ingredient that serves as a direct replacement for fluoride, Rennou™ promotes rapid remineralization of tooth enamel on contact. It is a carefully calculated formulation of Theobromine, Calcium, and Phosphate. Unlike fluoride, Rennou™ is entirely non-toxic and safe if swallowed.
  • Aqua/Water/Eau - serves as the primary vehicle for all other ingredients.
  • Hydrated Silica - acts as a thickening agent, a mild abrasive, and a whitening agent.
  • Xylitol - acts as a mild sweetener, and helps prevent bacterial growth on the enamel.
  • Sorbitol - acts as a thickening agent and flavor enhancer.
  • Glicerin - helps retain moisture and improve mouth-feel.
  • Sodium Lauroyl Sarcosinate - acts as a foaming agent and detergent, a safer alternative to SLS (sodium lauryl sulfate)
  • Xanthan Gum - a thickening agent, emulsifier, and stabilizer.
  • Titanium Dioxide - used in small concentrations to improve the color of the paste.
  • Citric acid - used to stabilize the formulation, and enhance flavor.
  • Sodium Bicarbonate - used as a mild abrasive to remove plaque.
  • Sodium benzoate - used as a preservative to prevent microbial growth in the tube.
  • Stevioside - (stevia)- used as a plant-based sweetener.
  • Mentha Viridis (Spearmint) Leaf Oil - gives the formula a refreshing spearmint flavor. This is used in both Theodent Classic and Theodent 300.
  • Natural Flavor/Aroma (Chocolate) - gives the Theodent Kids toothpaste its signature chocolate flavor that kids love.
  • Ekstrakt cvetov vanilije Planifolia – uporablja se v majhnih količinah za izboljšanje splošnega okusa.


Answers to all the questions you have about Theodent toothpaste.

Theodent is an American oral care company manufacturing a revolutionary line of fluoride-free dentifrices containing Rennou as an active ingredient. Theodent is great for everyone, and our clinical research indicates it’s particularly effective at remineralizing tooth enamel and reducing hypersensitivity.

Theodent is the best toothpaste in the world for relieving hypersensitivity. Research has shown that it takes 70 times more fluoride to have a comparable remineralization effect to Rennou™. Importantly, Rennou™ is non-toxic and a far better solution for relieving painful sensitivity. Many patients will feel results in as little as 3-7 days.

There are three toothpastes in the Theodent family. Theodent Classic toothpaste (spearmint flavor) and Theodent Kids toothpaste (chocolate chip flavor) are available here and at dental offices, pharmacies, grocers, natural food stores, and lifestyle boutiques near you and in select international markets. Theodent 300 toothpaste (spearmint flavor) is our clinical-strength toothpaste, similar in formulation to Theodent Classic but with an increased concentration of Rennou, the theobromine-based active ingredient. Theodent 300 can also be found in dental offices, pharmacies, grocers, lifestyle boutiques, and in famed luxury retailers like Harrod’s in London. Theodent 300 is known as “the world’s finest toothpaste. All three products are designed to be used as a twice-daily toothpaste.

Rennou is the safe-to-swallow active ingredient in all Theodent toothpaste products. Rennou is comprised of three components: theobromine, calcium, & phosphate. Theobromine is an amazing compound with many beneficial health properties and occurs naturally in the cacao plant. The ratio of theobromine, calcium, & phosphate in our formulation is proprietary and only efficacious in a specific combination. Clinical research indicates that Rennou is more effective than fluoride at remineralizing enamel and hardening teeth. Rennou, Theodent’s active ingredient, also has GRAS (generally regarded as safe) designation from the FDA, the highest standard in food safety. Theodent Toothpastes are currently the only toothpastes that contain Rennou.

Commercial chocolate generally contains cocoa fat and added sugar which is cariogenic (cavity-causing). Theodent’s interest in chocolate focuses only on one component of cacao, theobromine, which must first be refined into a pharmaceuticalgrade pure crystalline powder before it can be evenly distributed into our toothpaste.

Please refer to our page dedicated to the technology. It can be found here.

Theodent is designed to be used like any other toothpaste. We recommend brushing twice daily for two minutes. Rinse and repeat! Rennou™ works on contact, so for those with extreme sensitivity, you may choose to let the product sit on the tooth’s surface for a longer period of time before rinsing.

All Theodent products are fluoride-free and safe if swallowed. Our active ingredient, Rennou™, even has GRAS (generally regarded as safe) status from the FDA, the highest standard in food safety. In particular, chocolate chip-flavored Theodent Kids toothpaste is a fantastic product for adults worried about their children swallowing fluoride in their toothpaste.

Please refer to the ingredients page here, where we detail the ingredients and their functions in our formulation.

Theodent is formulated to remineralize on contact. Clinical data shows most patients see an effect from Theodent toothpaste in 3-7 days.

SLS is short for sodium laurel sulfate. Though it was common in toothpaste for decades, some people do experience rare side effects from it, like skin irritation in and around the mouth. Theodent products are proud to be SLS-free! Theodent Classic & Theodent 300 do contain similarly named sodium lauroyl sarcosinate, a coconut oil-derived replacement to SLS that offers a pleasant foamy texture without the risk of skin irritation. Theodent Kids does not contain either foaming agent.

There are no animal ingredients or animal-derived ingredients in any of Theodent’s products. Theodent products have never been and will never be tested on animals (other than humans)

All components of Theodent’s packaging are recyclable.

Theodent is manufactured in an FDA-inspected and approved facility in the United States. From start to finish, all Theodent components are sourced from North America.

Theodent products


Theodent Classic


Theodent Kids


Theodent 300


Theodent PACK3

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